Work

Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock

Year: 2015

Type: article

Study design: Observational Study

Abstract: CONTEXT: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. OBJECTIVE: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). METHODS: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). RESULTS: The area under the curve for ASSIST was greater than that of IL6 and PCT. CONCLUSIONS: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

Source: Biomarkers

DOI: 10.3109/1354750x.2014.1000971

Authors: Hector R. Wong, Keith R. Walley, Ville Pettilä, Nuala J. Meyer, James A. Russell, Sari Karlsson, Michael G. S. Shashaty, Christopher J. Lindsell

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of British Columbia, St. Paul's Hospital, Centre for Heart Lung Innovation, Helsinki University Hospital, University of Pennsylvania, Tampere University Hospital

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences

Awards: Genomic analysis of pediatric SIRS and septic shock, Novel diagnostic and stratification tools for septic shock, Genetic Variation in the ANGPT-TIE Pathway and Risk for Acute Lung Injury, Cincinnati Center for Clinical and Translational Sciences and Training

OpenAlex ID: W2018209491

FWCI: 1.568

Cites: 20

Cited by: 10

Related to: 10