An MBoC Favorite: High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli
Year: 2012
Type: article
Abstract: In celebration of MBoC's first 20 years, members of the Editorial Board, members of the ASCB Council, and others comment on their favorite MBoC papers from the past two decades.This article is my favorite MBoC paper, because I believe that it broke ground for a new field-the study of the role of nucleoli in genome organization.Van Koningsbruggen et al. (2010) demonstrate that parts of all chromosomes are associated with nucleoli in human cells.The association is biased toward more transcriptionally repressive and AT-rich regions of the genome.The patterns of nucleolar-associated chromatins partially overlap with nuclear lamina-associated chromatin domains and are heritable through cell cycles.Nucleoli and nuclear lamina have long been known to nucleate heterochromatin.However, little attention has been directed to exploring possible roles of nucleoli in global genome organization.This article, together with a study published in the same period by Nemeth et al. (2010), provided the first molecular evidence of the extensive interactions between nucleoli and the genome.These findings raise the possibility that nucleoli play a key role in anchoring and organizing the mammalian genome.
Source: Molecular Biology of the Cell
Author: Sui Huang
Institution: Northwestern University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2018242364