Work

RNAs of the human chromosome 15q11‐q13 imprinted region

Year: 2012

Type: review

Abstract: The human chromosome 15q11‐q13 region hosts a wide variety of coding and noncoding RNAs, and is also the site of nearly every imaginable type of RNA processing. To deepen the intrigue, the transcripts in the human chromosome 15q11‐q13 region are subject to regulation by genomic imprinting, and some of these transcripts are imprinted in a tissue‐specific manner. As the region is critically important for three human neurogenetic disorders, Angelman syndrome, Prader‐Willi syndrome, and 15q duplication syndrome, there is intense interest in understanding the types of RNA and RNA processing that occurs among the imprinted genes. This review summarizes what is known about the various RNAs within the imprinted domain, including a novel type of RNA that was only very recently identified. WIREs RNA 2013, 4:155–166. doi: 10.1002/wrna.1150 This article is categorized under: RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development

Source: Wiley Interdisciplinary Reviews - RNA

DOI: 10.1002/wrna.1150

Author: Stormy J. Chamberlain

Institution: UConn Health

Language: English

Topic: Genetic Syndromes and Imprinting

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Raymond and Beverly Sackler Foundation, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: G2801043853