Year: 2014
Type: article
Abstract: In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the desired analogues after full deprotection. In contrast to the parent 5-(4-fluoropheny)uridine phosphonate, the present extended-base uridine phosphonates essentially failed to modulate the P2Y2 receptor.
Source: Molecules
Authors: Lijun Song, Martijn Risseeuw, Izet Karalic, Matthew Barrett, Kyle Brown, T. Harden, Serge Van Calenbergh
Institutions: Ghent University, University of North Carolina at Chapel Hill
Language: English
Subfield: Physiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W2018389592