Variants in MCP1 and MCP1R are Associated with Baseline Muscle Size and Strength
Year: 2008
Type: article
Abstract: Recent research has implicated several chemokines and their receptors in the pathogenesis of many conditions, including muscle damage and repair. Chemokines and chemokine receptors are members of the inflammatory system in skeletal muscle; examining genetic variation in the genes encoding these proteins may help explain inter-individual differences in muscle, fat, and bone phenotypes as well as differences in the response to resistance training. PURPOSE: We set out to determine if genetic variants of 2 inflammatory genes active in muscle (MCP1 and MCP1R) showed associations with muscle size or strength and the response to resistance training. METHODS: 1200 college-aged subjects underwent a 12 wk supervised strength training program for the upper arm muscles. Muscle size (via MRI) and strength measurements (1 RM and isometric) were taken before and after training. The study participants were then genotyped for genetic variants in the chemokine gene MCP1 (rs3760396, rs2857656, rs4586, rs13900) and the chemokine receptor gene MCP1R (rs3918358 and rs1799864). RESULTS: In females, the C allele of the rs2857656 SNP was associated with higher baseline (1-RM and isometric) muscle quality and lower baseline subcutaneous fat volume (p = 0.0179, p = 0.0415, and p = 0.0118, respectively). In males, the C allele was associated with higher baseline strength (1-RM) and baseline torque (p = 0.0050 and p = 0.0044, respectively). For SNP rs4586, the C allele was associated with higher baseline strength (1-RM and isometric, p = 0.0185 and p = 0.0264, respectively) and with higher baseline torque (1-RM and isometric, p= 0.0105 and p = 0.0204, respectively) in males only. In females, the T allele of the rs13900 SNP was associated with higher baseline (1-RM and isometric) muscle quality and lower baseline subcutaneous fat volume (p = 0.0156, p = 0.0282, and p = 0.0270, respectively). In males, the T allele of this SNP was associated with higher baseline strength (1-RM and isometric), torque, and higher cortical bone volume (p= 0.0029, p = 0.0476, p = 0.0023, and p = 0.0478, respectively). CONCLUSIONS: Variants in the MCP1 and MCP1R genes show strong associations with several body composition components, indicating that inflammatory/immune genes in skeletal muscle contribute to the multigenic system that determines overall body composition.
Authors: Brennan T. Harmon, Kasra Adham, Ronak R. Patel, Justin S. Larkin, Heather Gordish-Dressman, Funda Suer, Monica Hubal, Priscilla M. Clarkson, Paul D. Thompson, Theodore J. Angelopoulos, Paul M. Gordon, Niall M. Moyna, Linda S. Pescatello, Paul S. Visich, Robert F. Zoeller, Laura L. Tosi, Eric P. Hoffman, Joseph M. Devaney
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2018409806