Rapid Degradation of Oseltamivir Phosphate in Clinical Samples by Plasma Esterases
Year: 2006
Type: article
Abstract: The anti-influenza drug oseltamivir is an ester prodrug activated by hepatic carboxylesterases. Plasma esterases also convert up to 31.8% of the parent compound to the active metabolite after 4 h ex vivo, with wide interindividual variation. This source of error is removed by adding the esterase inhibitor dichlorvos to blood collection tubes.
DOI: 10.1128/aac.00500-06
Institutions: Mahidol University, University of Oxford, University of Liverpool
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G2648042062, G9000290420
OpenAlex ID: W2018422760