Work

Cantharidin Combined with Chemotherapy for Chinese Patients with Metastatic Colorectal Cancer

Year: 2015

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: BACKGROUND: This systematic analysis was conducted to evaluate the efficacy and safety of cantharidin combined with chemotherapy in treating Chinese patients with metastatic colorectal cancer. METHODS: Clinical studies evaluating the efficacy and safety of cantharidin combined with chemotherapy on response and safety for Chinese patients with colorectal cancer were identified using a predefined search strategy. Pooled response rate (RR) of treatment were calculated. RESULTS: When cantharidin combined with chemotherapy, 4 clinical studies which included 155 patients with advanced colorectal cancer were considered eligible for inclusion. The systematic analysis suggested that, in all patients, pooled RR was 46.5% (72/155) in cantharidin combined regimens. Major adverse effects were neutropenia, leukopenia, fatigue, and anemia with cantharidin combined treatment; no treatment related deaths occurred. CONCLUSION: This systematic analysis suggests that cantharidin combined regimens are associated with high response rate and accepted toxicity in treating Chinese patients with metastatic colorectal cancer suggesting that randomized clinical trials are now warranted.

Source: Asian Pacific Journal of Cancer Prevention

DOI: 10.7314/apjcp.2014.15.24.10977

Authors: Li Han, Yi-Jie Sun, Yong-Fu Pan, Hao Ding, Xi Chen, Xu Zhang

Institutions: Fudan University, Huadong Hospital

Language: English

Topic: Beetle Biology and Toxicology Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200