Work

Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy

Year: 2007

Type: article

Abstract: Photoacoustic microscopy was used to noninvasively image variations in hemoglobin oxygen saturation (SO2) in the subcutaneous microvasculature of rats in vivo. In phantom tests, the calculated concentration fractions of red ink in double-ink mixtures matched the actual values with a 1% error. In ex vivo studies, the calculated SO2 in bovine blood agreed with the standard spectrophotometric measurements within a 4% systematic difference. In in vivo studies, arteries and veins were separated based on the measured SO2 values and variations in SO2 between different physiological states (hyperoxia, normoxia, and hypoxia) were imaged in single blood vessels.

Source: Applied Physics Letters

DOI: 10.1063/1.2435697

Authors: Hao F. Zhang, Konstantin Maslov, Mathangi Sivaramakrishnan, Gheorghe Stoica, Lihong V. Wang

Institutions: Texas A&M University, Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering