Applications of sensitivity analysis for drug discovery and development in the ErbB receptor network
Year: 2007
Type: article
Abstract: We are using quantitative biochemical network models of receptor signaling to yield significant improvements in drug design and decision-making throughout the development of our therapeutics. As an example, we have developed a model of the ErbB receptor network that includes ErbB1-4, ligand-receptor binding of different ErbB ligands, receptor trafficking, and intracellular signal transfer leading to ERK and Akt phosphorylation. The model is first trained using quantitative experimental data and then our in silico predictions are verified by an independent set of experiments.
Source: BMC Systems Biology
Authors: B Harms, A Lee, R Paxson, UB Nielsen, B Schoeberl
Language: English
Topic: HER2/EGFR in Cancer Research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,290
OpenAlex ID: W2018552830