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Melatonin administration protects CA1 hippocampal neurons after transient forebrain ischemia in rats

Year: 1997

Type: article

Abstract: Melatonin administered at the beginning of cerebral reperfusion protected CA1 neurons against 10, 20 and 30 min of transient forebrain ischemia. Intraperitoneal injections of saline or melatonin (10 mg/kg) were given after 0, 2 and 6 h, or 1, 2 and 6 h of cerebral reperfusion, or 30 min prior to ischemia. One week later, quantitative histological analysis demonstrated that CA1 neuronal density was significantly increased in the melatonin groups that were treated at 0, 2, 6 h compared to the saline-treated controls. Ischemic protection of CA1 was lost in the animals in which the melatonin treatment was delayed by 1 h, or given 30 min prior to the ischemia.

Source: Brain Research

DOI: 10.1016/s0006-8993(97)00188-1

Authors: Sunghee Cho, Tong H Joh, Hyung Hwan Baik, Christine Dibinis, Bruce T Volpe

Institutions: Cornell University, Burke Medical Research Institute

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360