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Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

Year: 2009
Type: article
Abstract: A new family of guanidinium-rich molecular transporters featuring a novel oligocarbonate backbone with 1,7-side chain spacing is described. Conjugates can be rapidly assembled irrespective of length in a one-step oligomerization strategy that can proceed with concomitant introduction of probes (or by analogy drugs). The new transporters exhibit excellent cellular entry as determined by flow cytometry and fluorescence microscopy, and the functionality of their drug delivery capabilities was confirmed by the delivery of the bioluminescent small molecule probe luciferin and turnover by its intracellular target enzyme.
DOI: 10.1021/ja907363k
Authors: Christina B. Cooley, Brian M. Trantow, Fredrik Nederberg, Matthew K. Kiesewetter, James L. Hedrick, Robert M. Waymouth, Paul A. Wender
Language: English
Open Access status: green
Awards: SYNTHETIC STUDIES ON TUMOR PROMOTERS AND INHIBITORS, Synthetic Studies Related to Cancer Research/Treatment, G433345679, Synthetic Studies on Tumor Promoters and Inhibitors, G844802523, Synthetic Studies Related to Cancer Research/Treatment
OpenAlex ID: W2018682207
FWCI: 4.156
Cites: 35
Cited by: 123
Related to: 10