Hydrogels: Injectable Hydrogels with In Situ Double Network Formation Enhance Retention of Transplanted Stem Cells (Adv. Funct. Mater. 9/2015)
Year: 2015
Type: article
Abstract: S. C. Heilshorn and co-workers design shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) by combining protein-engineering and synthetic polymer technologies. On page 1344, stem cell transplantation using SHIELD results in a 400% increase in one-week cell retention compared to cell delivery in saline, the clinical standard. These materials work by providing a “shield” against cell membrane damage during injection and then stiffening in situ to create a scaffold for cell attachment.
Source: Advanced Functional Materials
Authors: Lei Cai, Ruby E. Dewi, Sarah C. Heilshorn
Institution: Stanford University
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2018756546