Year: 2010
Type: article
Abstract: Stopping by Woods on a Snowy Evening".Scholars have posited that "the woods" represent temptation and sin, while the "miles to go before I sleep" suggest one's obligations to a higher being, self, loved ones, or society before the end of one's life.As with many worthy goals, identification of markers predictive of subsequent treatment responses is a challenging and difficult task, and researchers have many hurdles to overcome in this quest.In this issue, Plant et al. publish results of a genome-wide association study (GWAS) of predictors of anti-TNF treatment in rheumatoid arthritis (RA).Inadequate response occurs in 30-40% of RA patients treated with anti-TNF agents.These drugs are expensive, costing as much as $15,000 to $30,000 US dollars per year.Given that the survival of RA patients has improved over the years, and that 0.5 to 1.0% of the US population is affected by RA, the financial cost to the health care system is substantial.
Source: Arthritis & Rheumatism
DOI: 10.1002/art.30126
Authors: Robert M. Plenge, S. Louis Bridges
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2018783923