Work

Optical coherence tomography for the quantitative study of cerebrovascular physiology

Year: 2011

Type: article

Abstract: Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

Source: Journal of Cerebral Blood Flow & Metabolism

DOI: 10.1038/jcbfm.2011.19

Authors: Vivek J Srinivasan, Dmitriy N Atochin, Harsha Radhakrishnan, James Y Jiang, Svetlana Ruvinskaya, Weicheng Wu, Scott Barry, Alex E Cable, Cenk Ayata, Paul L Huang, David A Boas

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts Institute of Technology, Thorlabs (United States)

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: G182365684, G2213582121, G2529054258, G3271126441, Remodeling and recovery in the neurovascular unit, G5221029075, G532418274, Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology

OpenAlex ID: W2018879210

FWCI: 4.013

Cites: 23

Cited by: 72

Related to: 10