Comparative Effectiveness Research in Cancer: What Has Been Funded and What Knowledge Gaps Remain?
Year: 2013
Type: article
Abstract: A recent explosion of interest in comparative effectiveness research (CER) has been accompanied by diverse attempts to define CER and specify CER research methods. We explore how CER is relevant across the cancer control continuum, including prevention, screening, diagnosis, treatment, and survivorship. We review cancer CER research funded by the National Cancer Institute by analyzing project characteristics along the dimensions of cancer type, stage of the cancer continuum, position on the T0 to T4 translational continuum, and the size and representativeness of both the settings and populations studied. We also provide an assessment of cost and resources considerations in CER. One hundred three relevant projects on CER were funded by the National Cancer Institute’s Division of Cancer Control and Population Science between 2009 and 2011. Prevention studies were most frequent (38.8%), and survivorship grants were least frequent (13.5%). Many projects included economic (35.0%) or simulation modeling (10.7%) approaches as well as multilevel behavioral (53.4%) and/or organizational change (54.4%) interventions. Most studies used convenience sampling (54.3%) and studied two or less settings (50.0%). Cancer CER is active and diverse but could be enhanced by a greater focus on knowledge integration, context, relevance to stakeholders, transparency, and population impact.
DOI: 10.1093/jnci/djt066
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2018886052