Work

Myeloid derived suppressor cells

Year: 2013

Type: article

Abstract: The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent discovery and characterization, anti-MDSC agents have been identified, which may improve immunotherapy efficacy.

Source: OncoImmunology

DOI: 10.4161/onci.24117

Authors: Todd J. Waldron, Jon G. Quatromoni, Tatiana A. Karakasheva, Sunil Singhal, Anil K. Rustgi

Institutions: Abramson Cancer Center, University of Pennsylvania, Hospital of the University of Pennsylvania, Veterans Health Administration, Philadelphia VA Medical Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913