Work

The Need for Integrative Computational Oncology: An Illustrated Example through MMP-Mediated Tissue Degradation

Year: 2013

Type: article

Abstract: PHYSICAL ONCOLOGY IS A GROWING FORCE IN CANCER RESEARCH, AND IT IS ENHANCED BY INTEGRATIVE COMPUTATIONAL ONCOLOGY: the fusion of novel experiments with mathematical and computational modeling. Computational models must be assessed with accurate numerical methods on correctly scaled tissues to avoid numerical artifacts that can cloud analysis. Simulation-driven analyses can only be validated by careful experiments. In this perspectives piece, we evaluate a current, widespread model of matrix metalloproteinase-driven tissue degradation during cancer invasion to illustrate that integrative computational oncology may not realize its fullest potential if either of these critical steps is neglected.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2013.00194

Authors: Shannon M. Mumenthaler, Gianluca D’Antonio, Luigi Preziosi, Paul Macklin

Institutions: University of Southern California, Politecnico di Torino

Language: English

Topic: Mathematical Biology Tumor Growth

Subfield: Modeling and Simulation

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801