Work

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

Year: 2008

Type: preprint

Abstract: Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. Conversely, overexpression of Elf5 in an inducible transgenic model caused alveolar differentiation and milk secretion in virgin mice, disrupting ductal morphogenesis. CD61+ luminal progenitor cells accumulated in Elf5-deficient mammary glands and were diminished in glands with Elf5 overexpression. Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development.

Source: Genes & Development

DOI: 10.1101/gad.1614608

Authors: Samantha R. Oakes, Matthew J. Naylor, Marie-Liesse Asselin-Labat, Katrina D. Blazek, Margaret Gardiner-Garden, Heidi N. Hilton, Michael Kazlauskas, Melanie A. Pritchard, Lewis A. Chodosh, Peter L. Pfeffer, Geoffrey J. Lindeman, Jane E. Visvader, Christopher J. Ormandy

Institutions: Garvan Institute of Medical Research, UNSW Sydney, Walter and Eliza Hall Institute of Medical Research, Hudson Institute, Monash Institute of Medical Research, University of Pennsylvania, AgResearch

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Cancer Australia, Cancer Institute NSW, Medical Research Council, National Health and Medical Research Council, Cancer Council NSW

OpenAlex ID: W2019171053

Cites: 21

Cited by: 260

Related to: 10