Work

Neuroblastoma: Issues in Transplantation

Year: 2012

Type: article

Abstract: Neuroblastoma (NBL) is the most common extra-cranial solid malignancy of childhood, and has a broad spectrum of clinical presentations and behavior. Although low- and intermediate-risk NBL are mostly curable [1,2], high-risk NBL has proven refractory to conventional treatment modalities [3-5]. Despite the unsatisfactory responses to conventional therapies, some improvements in outcome have been achieved through the escalation of therapeutic intensity [6]. Although even the most intense conventional therapy results in long-term event-free survival (EFS) of much <40%, improvements in EFS can be achieved through the addition of consolidation therapy with high-dose therapies that exceed marrow tolerance.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2011.10.020

Authors: Stephan A. Grupp, Shahab Asgharzadeh, Gregory A. Yanik

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania, Children's Hospital of Los Angeles, University of Michigan, Michigan Medicine

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650