Work

Assessing mechanical sensitivity of masseter muscle in lightly anesthetized rats: A model for craniofacial muscle hyperalgesia

Year: 2006

Type: article

Abstract: In this report, we present a simple and reliable way of assessing mechanical sensitivity of masseter muscle as a model for craniofacial muscle hyperalgesia. Mechanical thresholds that evoke nocifensive hindpaw responses following noxious masseter stimulation were assessed. Masseteric injections of widely used sensitizing agents significantly increased mechanical sensitivity of the muscle in a time dependent manner without affecting other muscles and overlying skin. This lightly anesthetized rodent paradigm allows us to provide calibrated and reliable mechanical stimulus, which is not possible in behaving animals. The technique can be applied to study mechanistic bases for craniofacial muscle tenderness.

Source: Neuroscience Research

DOI: 10.1016/j.neures.2006.06.001

Authors: Jin Y. Ro, Norman F. Capra

Institution: University of Maryland, Baltimore

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,770