Imatinib resistant BCR‐ABL1 mutations at relapse in children with P h+ ALL : a C hildren's O ncology G roup ( COG ) study
Year: 2012
Type: article
Abstract: liver biopsies and hepatitis virus testing were not required in the protocol.Acute mutiorgan failure is a common cause of death in adult sickle cell patients without Hepatitis-C (Perronne et al, 2002; Manci et al, 2003; Darbari et al, 2006).Cirrhosis with severe iron overload is often found on autopsy studies in adults with sickle cell disease.Close monitoring of the liver functions in patients on deferasirox is indicated.However, multiple studies have found that deferasirox protects against iron-induced hepatic injury as well as fulminant hepatitis (Al-Rousan et al, 2011; Deugnier et al, 2011; Sato et al, 2011).In summary, the acute multiorgan failure observed in this patient was secondary to the underlying sickle cell disease and the evidence does not indicate deferasirox as a causal agent.
Source: British Journal of Haematology
Institutions: Oregon Health & Science University, OHSU Knight Cancer Institute, Children's Hospital Colorado, University of Colorado Anschutz, NYU Langone Health, New York University, Children's Hospital of Wisconsin, Medical College of Wisconsin, The University of Texas Southwestern Medical Center, University of British Columbia, BC Children's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2019300684