Year: 2008
Type: review
Abstract: Soluble cytokine receptors play key roles in regulating cytokine-mediated biological events by binding and modulating the activity of target ligands in either an antagonistic or agonistic fashion. This Minireview will provide an overview of the molecular mechanisms mediating the generation of soluble cytokine receptors, which include sheddase-mediated proteolytic cleavage of cell-surface receptors, generation of soluble receptors by alternative gene splicing, transcription and translation of cytokine-binding genes, and extracellular release of membranebound receptors within vesicles such as exosomes.Cytokine-mediated biological events such as host defense, immune regulation, cellular proliferation, and apoptosis are tightly controlled to prevent adverse sequelae secondary to dysregulated signaling.An important mechanism by which aberrant cytokine signaling is modulated is the generation of soluble cytokine receptors that bind target cytokines and modify their biological activity in an antagonistic or agonistic fashion.This Minireview will focus on the molecular mechanisms that modulate the generation of soluble cytokine receptors.
Source: Journal of Biological Chemistry
Author: Stewart J. Levine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2019434041