Year: 2014
Type: review
Abstract: The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in cholesterol transport from cells requires that they readily gain access to and function within interstitial fluid. Studies of lymph derived from skin, connective tissue, and adipose tissue have demonstrated that particles as large as HDLs require transport through lymphatics to return to the bloodstream during reverse cholesterol transport. Targeting HDL for therapeutic purposes will require understanding its biology in the extravascular compartment, within the interstitium and lymph, in health and disease, and we herein review the processes that mediate the transport of HDLs and chylomicrons through the lymphatic vasculature.
DOI: 10.1172/jci71610
Authors: Gwendalyn J. Randolph, Norman E. Miller
Institutions: Washington University in St. Louis, University of Oxford
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: bronze
Awards: G1873286573, Cholesterol and Lymphatic Transport of Molecules and Cells, Differentiation/migratory fate of monocyte-derived cells, VEGF-C/VEGFR3 AND LYMPHATIC TRANSPORT OF CHOLESTEROL FROM ATHEROSCLEROTIC PLAQUE, G8674824779, G9000110088, Differentiation and Function of Monocytes and Macrophages
OpenAlex ID: W2019543527