Work

Mechanisms of Oncogene Cooperation: Activation and Inactivation of a Growth Antagonist

Year: 1991

Type: article

Abstract: Gene transfer experiments have defined limitations with regard to the ability of individual oncogenes to transform cultured cells to a tumorigenic state. The stable transformation of REF52 cells by either the ras or sis oncogenes requires the continuous expression of a second collaborating oncogene, such as adenovirus-5 E1A or SV40 large T-antigen. Our studies suggest that the function of the nuclear collaborators is to antagonize dominant growth controls which limit the ability of REF52 cells to proliferate in response to mitogenic stimuli.

Source: Environmental Health Perspectives

DOI: 10.1289/ehp.919397

Authors: M M Ragozzino, A Kuo, J DeGregori, N Kohl, H E Ruley

Institution: Massachusetts Institute of Technology

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500