Work

Effects of Freezing on Collagen Nanoscale Structure in Engineered Tissues

Year: 2013

Type: conference-paper

Abstract: The present study aims to systematically investigate the freezing-induced changes that occur at multiple levels of organization of collagen nanostructure in the engineered tissues (ET). Collagen is a major constituent of the extracellular matrix (ECM) of biological tissues, and is also used for scaffold of engineered tissues and biomaterials [1, 2]. Given its abundance and widespread physiological function in vivo, a proper understanding of the relationships between the collagen’s structure, properties, and function is essential for the improvement of current tissue cryopreservation protocols that suffer from highly variable and tissue specific outcomes [3, 4].

Source: ASME Global Congress on NanoEngineering for Medicine and Biology (NEMB)

DOI: 10.1115/nemb2013-93125

Authors: Altug Ozcelikkale, Yan Li, Xianfan Xu, Bumsoo Han

Institution: Purdue University West Lafayette

Language: English

Topic: Collagen: Extraction and Characterization

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institute of Biomedical Imaging and Bioengineering, Division of Chemical, Bioengineering, Environmental, and Transport Systems