Thiocoraline, a New Depsipeptide with Antitumor Activity Produced by a Marine Micromonospora. I. Taxonomy, Fermentation, Isolation, and Biological Activities.
Year: 1997
Type: article
Abstract: A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-13-ACM2-092. Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092 was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28 cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compound binds to supercoiled DNA and inhibits RNA synthesis.
Source: The Journal of Antibiotics
Authors: FRANCISCO ROMERO, FERNANDO ESPLIEGO, JULIA PÉREZ BAZ, TERESA GARCÍA DE QUESADA, DOLORES GRÁVALOS, FERNANDO DE LA CALLE, JOSÉ LUIS FERNÁNDEZ-PUENTES
Institution: PharmaMar (Spain)
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2019692337