An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors
Year: 2007
Type: article
Abstract: Rodent incisors grow throughout adult life, but are prevented from becoming excessively long by constant abrasion, which is facilitated by the absence of enamel on one side of the incisor. Here we report that loss-of-function of sprouty genes, which encode antagonists of receptor tyrosine kinase signaling, leads to bilateral enamel deposition, thus impeding incisor abrasion and resulting in unchecked tooth elongation. We demonstrate that sprouty genes function to ensure that enamel-producing ameloblasts are generated on only one side of the tooth by inhibiting the formation of ectopic ameloblasts from self-renewing stem cells, and that they do so by preventing the establishment of an epithelial-mesenchymal FGF signaling loop. Interestingly, although inactivation of Spry4 alone initiates ectopic ameloblast formation in the embryo, the dosage of another sprouty gene must also be reduced to sustain it after birth. These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult.
Source: Development
DOI: 10.1242/dev.015081
Authors: Ophir D. Klein, David B. Lyons, Guive Balooch, Grayson W. Marshall, M. Albert Basson, Miroslav Peterka, Tomas Boran, Renata Peterkova, Gail R. Martin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: U.S. Department of Energy, Wellcome Trust, Grantová Agentura České Republiky, National Institutes of Health, Medical Research Council, National Institute of Dental and Craniofacial Research, Basic Energy Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1155558310, G1286236842, G1286251239, G1445641779, G1452071450, G1585209081, G1816284028, G1898711858, Characterization and Modification of Dental Hard Tissues, G30714459, G3083819904, G365575497, G382641700, Cell communication and signalling pathways that control morphogenesis of the cerebellum, G42916606, G4942781738, G5849692847, G650090426, G6818824665, G7008305238, G8214903687, G9000164050, G969889393
OpenAlex ID: W2019827914