Work

Synthesis of the Bridging Framework of Phragmalin-Type Limonoids

Year: 2012

Type: article

Abstract: An efficient synthesis of the octahydro-1H-2,4-methanoindene core of phragmalin-type limonoids, such as xyloccensins O and P, is reported. The success of the synthetic route is predicated on the use of network analysis in the retrosynthetic analysis and a Diels-Alder reaction for the synthesis of a key hydrindanone derivative.

Source: Organic Letters

DOI: 10.1021/ol300647k

Authors: Terry P. Lebold, Gary M. Gallego, Christopher J. Marth, Richmond Sarpong

Institution: University of California, Berkeley

Language: English

Topic: Phytochemical compounds biological activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of General Medical Sciences

Awards: Novel Strategies for Natural Products Synthesis, G5445932033, Rhodium-Catalyzed 1,2-Addition of Pinacolboronic Esters into Ketones