Year: 2011
Type: article
Abstract: Chronic inflammation has long been appreciated to play a critical role in tumor development and maintenance. Among the mechanisms involved in coordinating the initiation and resolution of inflammation are those responsible for modifying mRNA stability and/or translation. Several studies have linked the RNA-binding protein HuR, which increases mRNA stability, with malignant transformation. However, in this issue of the JCI, Yiakouvaki et al. compellingly demonstrate in mice that increased HuR activity in myeloid cells has a protective role in the onset of pathologic intestinal inflammation (i.e., colitis) and colitis-associated cancer (CAC). These observations highlight the need to understand the roles of HuR in distinct cell populations in vivo and suggest that enhancing HuR activity may be of clinical benefit in protecting against pathologic inflammation and cancer.
DOI: 10.1172/jci61677
Authors: Jacqueline C. Shultz, Charles E. Chalfant
Institutions: Virginia Commonwealth University, Vanderbilt University
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1140289417, G1160139270, G1168596608, Betal Integrin and Renal Tubulogenesis, The Role of Ceramide Kinase in Eicosanoid Synthesis, Structure Function Analysis of Integrins alpha1beta1 and alpha2beta2, Regulation of caspase 9 RNA splicing in NSCLC cancer, Sphingolipid Regulation of Caspase 9 Alternative Splicing, G9000067450, G9000233271
OpenAlex ID: W2019903284