Work

Real-time microscopic visualization of tissue response to laser thermal therapy

Year: 2007

Type: article

Abstract: We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution ( approximately 10 microm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.2714027

Authors: Benjamin J. Vakoc, Guillermo J. Tearney, Brett E. Bouma

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: Consortia for Improving Medicine with Innovation and Technology, National Institutes of Health, National Cancer Institute

Awards: Conformal laser thermal therapy for epithelial cancer, G5773594175