Work

Impact of protease inhibitors on intracellular concentration of tenofovir-diphosphate among HIV-1 infected patients

Year: 2015

Type: article

Study design: Observational Study

Abstract: Intracellular nucleoside reverse transcriptase inhibitor (NRTI) concentrations are associated with plasma HIV-1 response. Coadministration of protease inhibitors with NRTIs can affect intracellular concentrations due to protease inhibitor inhibition of efflux transporters. Tenofovir-diphosphate (TFV-DP) concentrations within peripheral blood mononuclear cells were compared among individuals receiving either atazanavir or darunavir-based regimens. There was a trend towards higher TFV-DP concentrations among women and among participants receiving atazanavir. TFV-DP intracellular concentrations were positively associated with undetectable plasma HIV-1 RNA.

Source: AIDS

DOI: 10.1097/qad.0000000000000659

Authors: Cecile D. Lahiri, Sijia Tao, Yong Jiang, Anandi N. Sheth, Edward P. Acosta, Vincent C. Marconi, Wendy S. Armstrong, Raymond F. Schinazi, Aswani Vunnava, Sara Sanford, Ighovwerha Ofotokun

Institutions: Emory University, University of Alabama at Birmingham, Atlanta VA Medical Center, University of Alabama, UAB Medicine

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences

Awards: Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Characterization and modulation of mucosal immunity for HIV prevention in women, Center for AIDS Research at Emory University

OpenAlex ID: W2020077911

FWCI: 1.559

Cites: 17

Cited by: 11

Related to: 10