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Depletion of CD3+ and/or CD14+ Cells From Cord Blood Improves Ex Vivo Expansion

Year: 2009
Type: article
Abstract: Cord blood (CB) is a viable alternative to bone marrow (BM) or mobilized peripheral blood (mPB) for transplantation. While CB is collected, typed, frozen and banked as a readily available source of ethnically-diverse tissue for transplant, a major limitation of CB transplantation is low cell dose leading to delayed engraftment and increased risk of engraftment failure. Ex vivo expansion of CB could improve transplant outcomes by increasing cell dose. Using a mesenchymal stem cell (MSC) co-culture system, significant levels of CD34+ cell expansion can be achieved.
DOI: 10.1016/j.bbmt.2008.12.087
Authors: H. Yang, S.N. Robinson, W.K. Decker, D. Xing, D. Steiner, J. Lu , de Lima M.J., R.E. Champlin, P.J. Simmons, E.J. Shpall
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2020133438
FWCI:
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