Weekly rituximab consolidation following four cycles of R‐ CHOP induction chemotherapy in very elderly patients with diffuse large B‐cell lymphoma: Consortium for improving survival of lymphoma study ( CISL )
Year: 2014
Type: article
Study design: Clinical Trial
Abstract: This study aimed to determine the objective response, toxicity, and clinical outcome of weekly rituximab consolidation after four cycles of R-CHOP21 in very elderly patients with DLBCL. A prospective, multi-institutional phase II trial was conducted on patients with previously untreated CD20(+) DLBCL who were older than 70 yr. Patients were treated with four cycles of R-CHOP21 followed by weekly consolidation with rituximab (375 mg/m(2) , four times infusion) (NCT01181999). We also compared the clinical outcomes with an historical case-matched control group treated conventionally with six cycles of R-CHOP21. A total of 51 patients with newly diagnosed DLBCL were enrolled at 15 institutes between June 2010 and September 2013. The median age was 76 yr (range: 70-89). Forty-one of the 51 patients completed the planned rituximab consolidation (R-consolidation). The overall response rate was 78.4%, comprising 74.5% with a complete response and 3.9% with a partial response. After a median follow-up of 20.3 months, 2-yr progression-free survival and overall survival were 63.9% and 68.7%, respectively. No serious toxicities were reported during rituximab consolidation. Weekly rituximab consolidation following four cycles of R-CHOP21 resulted in an acceptable response with high tolerability and could be a good compromise between efficacy and safety for elderly patients with DLBCL.
Source: European Journal Of Haematology
DOI: 10.1111/ejh.12459
Institutions: Chonnam National University Hwasun Hospital, Samsung Medical Center, Inje University, Inje University Busan Paik Hospital, Keimyung University Dongsan Medical Center, Keimyung University Dongsan Hospital, Dong-A University Hospital, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Ewha Womans University, Ewha Womans University Seoul Hospital, Pusan National University Hospital, Pusan National University, Jeonbuk National University Hospital, Jeonbuk National University, Korea Institute of Radiological and Medical Sciences, Soonchunhyang University, Hallym University, Chung-Ang University Hospital, Asan Medical Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Chonnam National University
OpenAlex ID: W2020142884