Synthesis and characterization of a ribavirin-3′, 5′-phosphate pentadecamer homoribopolymer bearing a 5′-amino tether group and a 3′-thymidine
Year: 1990
Type: article
Abstract: The synthesis of a pentadecamer of the 5'-phosphate of the antiviral nucleoside ribavirin (1'-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) has been achieved. This homoribopolymer is terminated at the 5'-position with an (6-aminohexyl)phosphate group to permit conjugation to a carrier and at the 3'-position by a thymidine-5'-phosphate. The synthesis was accomplished using the methyl phosphoramidite approach to oligoribonucleotides. The homoribopolymer was insensitive to ribonuclease A but was sensitive to ribonuclease T2 digestion.
Source: Nucleic Acids Research
Authors: M.I. Dawson, A.N. Jina, S. Torkelson, S. Rhee, M. Moore, D.A. Zarling, P.D. Hobbs
Institution: SRI International
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2020174501