Work

Role of the Nlrp3 Inflammasome in Microbial Infection

Year: 2011

Type: article

Abstract: The intracellular Nod-like receptor Nlrp3 has emerged as the most versatile innate immune receptor because of its broad specificity in mediating immune response to a wide range of microbial or danger signals. Nlrp3 mediates assembly of the inflammasome complex in the presence of microbial components leading to the activation of caspase-1 and the processing and release of the pro-inflammatory cytokines IL-1β and IL-18. In this review, we give an update on the recent literature examining the role of Nlrp3 inflammasome in response to fungal, bacterial, and viral infections.

Source: Frontiers in Microbiology

DOI: 10.3389/fmicb.2011.00012

Authors: Paras K. Anand, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti

Institution: St. Jude Children's Research Hospital

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801