Year: 2013
Type: article
Abstract: SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells.
Source: PLoS Pathogens
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Awards: G1774152001, Replicational Fidelity and Lentivial Pathogenesis, SAMHD1 controls dNTP pool and HIV sensitivity to NRTIs, Training in Cellular, Biochemical and Molecular Sciences, Protein Interactions Involved in Orthopoxvirus Envelopment, Uncovering poxvirus proteins involved in regulating the IMV to EV transition, Targeting PI3K/Akt Cell Survival Pathway as a Novel Anti-HIV Therapy, Replicational Fidelity and Lentiviral Pathogenesis, G9000063878, G9000081275
OpenAlex ID: W2020265617