Year: 2012
Type: article
Abstract: OBJECTIVE: Arterial and ventricular stiffening are characteristics of diabetes and aging which confer significant morbidity and mortality; advanced glycation endproducts (AGE) are implicated in this stiffening pathophysiology. We examined the association between HbA(1c), an AGE, with arterial and ventricular stiffness measures in older individuals without diabetes. RESEARCH DESIGN & METHODS: Baseline HbA(1c) was measured in 830 participants free of diabetes defined by fasting glucose or medication use in the Cardiovascular Health Study, a population-based cohort study of adults aged ≥ 65 years. We performed cross-sectional analyses using baseline exam data including echocardiography, ankle and brachial blood pressure measurement, and carotid ultrasonography. We examined the adjusted associations between HbA(1c) and multiple arterial and ventricular stiffness measures by linear regression models and compared these results to the association of fasting glucose (FG) with like measures. RESULTS: HbA(1c) was correlated with fasting and 2-hour postload glucose levels (r = 0.21; p<0.001 for both) and positively associated with greater body-mass index and black race. In adjusted models, HbA(1c) was not associated with any measure of arterial or ventricular stiffness, including pulse pressure (PP), carotid intima-media thickness, ankle-brachial index, end-arterial elastance, or left ventricular mass (LVM). FG levels were positively associated with systolic, diastolic and PP and LVM. CONCLUSIONS: In this sample of older adults without diabetes, HbA(1c) was not associated with arterial or ventricular stiffness measures, whereas FG levels were. The role of AGE in arterial and ventricular stiffness in older adults may be better assessed using alternate AGE markers.
Source: PLoS ONE
Institutions: National Institutes of Health, National Institute on Aging, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, University of California San Diego, VA San Diego Healthcare System, Kaiser Permanente, Brigham and Women's Hospital, Harvard University, VA Boston Healthcare System, Cornell University, Weill Cornell Medicine, University of Washington, University of Colorado Denver, University of Maryland, Baltimore, Johns Hopkins University, University of Pittsburgh, Beth Israel Deaconess Medical Center
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1220223050, G1416583647, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1909643007, G2194386449, G2217057004, Determinants and Cardiovascular Consequences of Diabetes in Older Adults, G277826483, G2800149121, G328935669, G3667269547, G3667528909, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4012114008, G4048755144, G423252844, G463297664, G4660668308, Glycemia Advanced Gylcation End products (AGEs) and Atherosclerosis in Diabetes, G4987078009, G5167412771, CHS Events Follow-up Study, G6226795708, CHS-Transition Phase, G687544517, G7286144250, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G777822606, G7999488110, G806768229, G8184890991, G8593276544, G859984287, G905887895, G960597250
OpenAlex ID: W2020444372