Work

Semi-artificial Fluorescent Molecular Machine for DNA Damage Detection

Year: 2004

Type: article

Abstract: The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.

Source: Nano Letters

DOI: 10.1021/nl048357e

Authors: Vladimir V. Didenko, Candace L. Minchew, Stewart Shuman, David S. Baskin

Institutions: Michael E. DeBakey VA Medical Center, Baylor College of Medicine

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Improved Diagnostic MRI around Metallic Implants, Free radicals detection in aging brain by fullerenes