Work

Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

Year: 2011

Type: article

Abstract: The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00126-11

Authors: Wang Hengzhuang, Hong Wu, Oana Ciofu, Zhijun Song, Niels Høiby

Institutions: Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, European Society of Clinical Microbiology and Infectious Diseases

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2020556581

FWCI: 3.159

Cites: 42

Cited by: 243

Related to: 9