Egf Signaling Regulates Hematopoietic Regeneration Following Total Body Irradiation
Year: 2012
Type: article
Abstract: VEGFR2+ sinusoidal endothelial cells are necessary for normal hematopoietic reconstitution following myelosuppressive chemo- or radiotherapy (Hooper et al, Cell Stem Cell 2009). However, the mechanisms through which BM endothelial cells promote HSC regeneration remain unknown. We developed a mouse model in which mice bearing cell-specific deletion of Bak and Bax in Tie2+ cells (Tie2Cre;Bak1-/-;BaxFl/- mice) were irradiated with sublethal and lethal doses of total body irradiation to assess whether protection of BM Tie2+ ECs from radiation-induced apoptosis could protect the hematopoietic compartment from myeloablative toxicity.
Authors: P.L. Doan, J.L. Russell, H.A. Himburg, K. Helms, J.M. Sullivan, L.B. Jeffords, N.J. Chao, D.G. Kirsch, J.P. Chute
Institution: Duke Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2020785140