High epithelial lining fluid concentrations of NKTR-061 (inhaled amikacin) twice daily achieved in pneumonic portions of lung
Year: 2008
Type: conference-abstract
Abstract: The use of systemic aminoglycosides to treat ventilated patients with Gram-negative pneumonia (GNP) is limited by their toxicity and poor penetration into the lung. Luyt and colleagues demonstrated high amikacin epithelial lining fluid (ELF) concentrations after NKTR-061 twice daily, amikacin 400 mg (3.2 ml), administration to intubated patients with pneumonia ( n = 4) [ 1 ]. The present study was conducted to confirm high levels of NKTR-061 in the ELF in the pneumonic portion of the lung after 400 mg twice daily dosing.
Source: Critical Care
DOI: 10.1186/cc6262
Authors: J Chastre, K Corkery, C Wood, M Clavel, K Guntupalli, D Gribben, C Luyt
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Awards: Avaliacao da resposta inflamatoria durante hemodiluicao normovolemica aguda., Avaliacao da volemia por meio da variacao da pressao sistolica e debito cardiacao pela analise de contorno de pulso (picco) em modelo experimental de hemodiluicao normovolemica aguda., Análise contínua de medidas de cateter de artéria pulmonar volumétrico, ecotransesofágico, variações da pressão arterial sistêmica e marcadores de hipoperfusão tissular no choque hemorrágico em porcos
OpenAlex ID: W2020831342