Work

Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides

Year: 2010

Type: article

Abstract: We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01080-10

Authors: Nathaniel P. Chongsiriwatana, Tyler M. Miller, Modi Wetzler, Sergei Vakulenko, Amy J. Karlsson, Sean P. Palecek, Shahriar Mobashery, Annelise E. Barron

Institutions: Northwestern University, Stanford University, University of Wisconsin–Madison, University of Notre Dame

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: Ampetoids as Biostable Functional Mimics of Antimicrobial Peptides, G2625482007, G2695764258, Development of a Biomimetic Lung Surfactant Replacement

OpenAlex ID: W2020873347

FWCI: 8.226

Cites: 40

Cited by: 126

Related to: 10