Work

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres

Year: 1995

Type: article

Abstract: We generated mice with a null mutation of the forebrain-restricted transcription factor BF-1 to examine its function in brain development. Heterozygous animals have an apparently normal phenotype. Homozygous null BF-1 mutants die at birth and have a dramatic reduction in the size of the cerebral hemispheres. The development of the ventral telencephalon is more severely affected than that of the dorsal telencephalon. Telencephalic neuroepithelial cells are specified in the BF-1 mutant, but their proliferation is reduced. Dorsal telencephalic neuroepithelial cells also differentiate prematurely, leading to early depletion of the progenitor population. These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation.

Source: Neuron

DOI: 10.1016/0896-6273(95)90262-7

Authors: Shouhong Xuan, Carlos A Baptista, Gabriela Balas, Wufan Tao, Vera C Soares, Eseng Lai

Institutions: Memorial Sloan Kettering Cancer Center, Cornell University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $10,400

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development