Work

FSH and testosterone signaling in Sertoli cells

Year: 2005

Type: review

Abstract: Testosterone and follicle-stimulating hormone (FSH) are required to obtain full reproductive potential. In the testis, somatic Sertoli cells transduce signals from testosterone and FSH into the production of factors that are required by germ cells as they mature into spermatozoa. Recent advances in identifying new signaling pathways that are regulated by FSH and testosterone have allowed for refinement in the understanding of the independent, overlapping and synergistic actions of these hormones. In this review, we discuss the signaling pathways that are regulated by FSH and testosterone as well as the resulting metabolic and gene expression changes that occur as related to Sertoli cell proliferation, differentiation and the support of spermatogenesis.

Source: Reproduction

DOI: 10.1530/rep.1.00358

Authors: William H Walker, Jing Cheng

Institution: University of Pittsburgh

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: Nongenomic Androgen Signaling in Sertolli Cells