Work

Optical gradient flow focusing

Year: 2007

Type: article

Abstract: This paper describes a new method for carrying out flow cytometry, which employs optical gradient forces to guide and focus particles in the fluid flow. An elliptically shaped Gaussian beam was focused at the center of a microchannel to exert radiation pressure on suspended nanoparticles that are passing through the channel, such that these particles are guided to the center of the channel for efficient detection and sorting. To verify the efficiency of this optical-gradient-flow-focusing method, we present numerical simulations of the trajectories of the nanoparticles in both electroosmotic flow (EOF) and pressure-driven flow (PDF).

Source: Optics Express

DOI: 10.1364/oe.15.006167

Authors: Yiqiong Zhao, Bryant S. Fujimoto, Gavin D. Jeffries, Perry G. Schiro, Daniel T. Chiu

Institution: University of Washington

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,270

Funders: National Science Foundation, Alfred P. Sloan Foundation, University of Washington