Work

ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases

Year: 2009

Type: review

Abstract: Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia. Proteolytic cleavage has an important role in regulating the activity of these channels by increasing their open probability. Specific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at defined sites within their extracellular domains. This minireview addresses the mechanisms by which proteases activate this channel and the question of why proteolysis has evolved as a mechanism of channel activation.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r800083200

Authors: Thomas R. Kleyman, Marcelo D. Carattino, Rebecca P. Hughey

Institution: University of Pittsburgh

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: American Society of Nephrology, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases