Work

A unique signature identifies a family of zinc‐dependent metallopeptidases

Year: 1989

Type: article

Abstract: The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)80471-5

Authors: C.Victor Jongeneel, Jacques Bouvier, Amos Bairoch

Institutions: Ludwig Cancer Research, University of Lausanne, University of Geneva

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2021807514

FWCI: 16.19

Cites: 29

Cited by: 464

Related to: 10