Work

Identification of a thrombin receptor with factor Xa receptor and tissue factor in human pancreatic carcinoma cells

Year: 1995

Type: article

Abstract: Venous thromboembolism is a common feature of pancreatic cancer. The underlying mechanism is unclear, but is likely to involve thrombin generation on the cell surface. Human pancreatic carcinoma cell lines (n=8) have been studied immmunohistochemically for the expression of tissue factor, factor Xa receptor, and thrombin receptor. Each antigen had a distinct pattern of immunoreactivity in cell membrane and cytoplasm. Tissue factor was predominantly localised to the membrane, whereas thrombin and factor Xa receptor were largely cytoplasmic in distribution. The results support the hypothesis of a coagulation cascade that starts with tissue factor, leads to thrombin generation, and might confer a biological advantage on tumour cells.

Source: Molecular Pathology

DOI: 10.1136/mp.48.5.m288

Authors: A K Kakkar, N R Lemoine, S R Stone, D Altieri, R C N Williamson

Institutions: University of Cambridge, Yale University

Language: English

Topic: Blood Coagulation and Thrombosis Mechanisms

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2021840404