Year: 2007
Type: article
Abstract: Age-related macular degeneration (AMD), the most common cause of blindness in the elderly, is characterized by degeneration of the macula and can lead to loss of fine color vision. Alterations in inflammatory and immune system pathways, which arise from genetic differences, predispose individuals to AMD. Yet the mechanism of disease progression with respect to inflammation is not fully understood. In this issue of the JCI, the study by Combadière and colleagues shows that CX3C chemokine receptor 1-deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD.
DOI: 10.1172/jci33513
Authors: Jing Chen, Kip M. Connor, Lois E.H. Smith
Institutions: Boston Children's Hospital, Harvard University
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Awards: Developmental Retinal Neovascularization, G2493460474, Dietary Control Angiogenesis in Retinopathy, Surrogate Markers for Early Stage Diabetic Retinopathy, G5586389099, G6910885866, G7108373570, Intellectual and Developmental Disablities Research Center, G9000042107, Training Program in the Molecular Bases of Eye Disease, Dietary control of angiogenesis in retinopathy models, G916313173
OpenAlex ID: W2021852875