Work

Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

Year: 1976

Type: article

Abstract: Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.73.10.3719

Authors: G Kent, S Gay, T Inouye, R Bahu, O T Minick, H Popper

Institutions: Northwestern University, Max Planck Society, City University of New York, Max Planck Institute of Biochemistry, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2021964163

FWCI: 10.96

Cites: 15

Cited by: 348

Related to: 9